Functional role of the Frizzled linker domain in the Wnt signaling pathway
oleh: Seung-Bum Ko, Emiko Mihara, Yedarm Park, Kyeonghwan Roh, Chanhee Kang, Junichi Takagi, Injin Bang, Hee-Jung Choi
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-05-01 |
Deskripsi
The linker domain of Frizzled receptors has a varying effect on the functional levels of canonical and non-canonical Wnt signaling, with FZD chimeras influencing the binding of Wnt proteins and the recruitment of proteins regulating downstream signaling.