Fe/Mn Multilayer Nanowires as High-Performance T<sub>1</sub>-T<sub>2</sub> Dual Modal MRI Contrast Agents
oleh: Xiaoming Cao, Liyuan Gu, Shike Hu, Aiman Mukhtar, Kaiming Wu
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2021-04-01 |
Deskripsi
A lot of nanomaterials are using T<sub>1</sub>-T<sub>2</sub> dual mode magnetic resonance (MR) contrast agents (CAs), but multilayer nanowire (NW) with iron (Fe) and manganese (Mn) as T<sub>1</sub>-T<sub>2</sub> dual modal CAs has not been reported yet. Herein, we synthesized a Fe/Mn multilayer NW with an adjustable Fe layer, as T<sub>1</sub>-T<sub>2</sub> dual-mode CAs. The relaxation performance of Fe/Mn multilayer NW was studied at 1.5 T. Results show that, when the length of the Fe layer is about 10 nm and the Mn is about 5 nm, the r<sub>1</sub> value (21.8 mM<sup>−1</sup>s<sup>−1</sup>) and r<sub>2</sub> value (74.8 mM<sup>−1</sup>s<sup>−1</sup>) of the Fe/Mn multilayer NW are higher than that of Mn NW (3.7 mM<sup>−1</sup>s<sup>−1</sup>) and Fe NW (59.3 mM<sup>−1</sup>s<sup>−1</sup>), respectively. We predict that our Fe/Mn multilayer NW could be used as T<sub>1</sub>-T<sub>2</sub> dual mode MRI CAs in the near future.