One pot three components solvent free synthesis of 4-substituted phenyl-2-(sulfanyl/oxo) pyrimidine-5-carboxylate derivatives
oleh: Sourav Handique, Priyanka Sharma
| Format: | Article |
|---|---|
| Diterbitkan: | Elsevier 2022-01-01 |
Deskripsi
An efficient and simple procedure for synthesis of 3,4-dihydropyrimidinone or 3,4-thioxopyrimidinone maintaining eco-friendly protocol by introducing acetic acid as an organo-catalyst in presence of molecular sieves as water absorbent is disclosed. This new approach includes solvent free condition, short reaction duration, and easy isolation with high yield over classical Biginelli reaction..