Accurate estimation of cell composition in bulk expression through robust integration of single-cell information
oleh: Brandon Jew, Marcus Alvarez, Elior Rahmani, Zong Miao, Arthur Ko, Kristina M. Garske, Jae Hoon Sul, Kirsi H. Pietiläinen, Päivi Pajukanta, Eran Halperin
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-04-01 |
Deskripsi
Traditional methods for determining cell type composition lack scalability, while single-cell technologies remain costly and noisy compared to bulk RNA-seq. Here, the authors present a highly efficient tool to measure cellular heterogeneity in bulk expression through robust integration of single-cell information.