Stochastic pausing at latent HIV-1 promoters generates transcriptional bursting
oleh: Katjana Tantale, Encar Garcia-Oliver, Marie-Cécile Robert, Adèle L’Hostis, Yueyuxiao Yang, Nikolay Tsanov, Rachel Topno, Thierry Gostan, Alja Kozulic-Pirher, Meenakshi Basu-Shrivastava, Kamalika Mukherjee, Vera Slaninova, Jean-Christophe Andrau, Florian Mueller, Eugenia Basyuk, Ovidiu Radulescu, Edouard Bertrand
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2021-07-01 |
Deskripsi
The ability of HIV to alternate between acute and latent forms is thought to rely on a transcriptional feedback loop where polymerase pausing is released by the viral protein Tat. Here, the authors show that viral genome transcription can occur in a burst-like stochastic manner in the absence of Tat.