Effectiveness and safety of lower dose prednisone for initial treatment of acute graft-versus-host disease: a randomized controlled trial
oleh: Marco Mielcarek, Terrence Furlong, Barry E. Storer, Margaret L. Green, George B. McDonald, Paul A. Carpenter, Mary E.D. Flowers, Rainer Storb, Michael Boeckh, Paul J. Martin
| Format: | Article |
|---|---|
| Diterbitkan: | Ferrata Storti Foundation 2015-06-01 |
Deskripsi
We conducted a phase III study to test the hypothesis that initial therapy with “lower dose” prednisone is effective and safe for patients with newly diagnosed acute graft-versus-host disease. We hypothesized that a 50% decrease in the initial dose of prednisone for treatment of acute graft-versus-host disease would suffice to control graft-versus-host disease without increasing the incidence of secondary treatment. Patients with grade IIa manifestations (upper gastrointestinal symptoms, stool volumes