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<b>Introduction</b>: The study evaluated the selected appetite hormones (ghrelin, leptin) and inflammatory parameters (tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6)) in patients with urolithiasis, metabolic syndrome (MetS), and hyperuricemia. <b>Materials:</b> 57 patients with urolithiasis, MetS and hyperuricemia (UP group) and 29 healthy people as the control group (CG group) were recruited to the study. All persons were 22–60 age. <b>Methods:</b> After preliminary testing, the qualified participants were evaluated for fasting serum levels of ghrelin, leptin, IL-6, and TNF-α. <b>Results:</b> Our results revealed differences between average values of leptin (<i>p</i> = 0.045), ghrelin (<i>p</i> < 0.001), IL-6 (<i>p</i> < 0.001), and TNF-α (<i>p</i> < 0.001) in the studied groups. Moreover, in the UP group, significant correlations were found between ghrelin and leptin; between these hormones and IL-6, and between leptin and uric acid (UA). Besides, leptin concentration increased significantly along with the changes in the body mass index (BMI) categories in the UP group. <b>Conclusions:</b> This study showed that patients with urolithiasis, concomitant MetS, and high UA levels may have problems managing appetite hormones.