Traceless cysteine-linchpin enables precision engineering of lysine in native proteins
oleh: Neelesh C. Reddy, Rajib Molla, Pralhad Namdev Joshi, Sajeev T. K., Ipsita Basu, Jyotsna Kawadkar, Neetu Kalra, Ram Kumar Mishra, Suman Chakrabarty, Sanjeev Shukla, Vishal Rai
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-10-01 |
Deskripsi
Controlling the selectivity of the chemical modification of a genetic-manipulation-free protein is currently problematic. Here the authors report a method using cysteine-based chemoselective Linchpin Directed site-selective Modification of the lysine residue in a protein.