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Introduction. The implications of oxidative stress and inflammation are unanimously accepted in thyroid disease. Objective. The aim of our study was to find correlations between serum antioxidant markers: glutathione peroxidase-3 (GPx-3), thioredoxin (Trx), total antioxidant capacity (TAC), inflammatory marker IL-8 and thyroid hormones, TSH and anti-thyroperoxidase antibodies (ATPO antibodies). Patients with different thyroid disorders were compared. Materials and methods. The study included 57 patients (men and women), divided into three groups: 26 patients with hyperthyroidism, 19 patients with hypothyroidism and 12 patients with autoimmune thyroiditis. The control group was represented by 33 healthy subjects. All the participants provided the informed consent for this study. Results. Our results showed that the patients with autoimmune thyroiditis had the highest level of Il-8 and the lowest TAC. Both Trx and GPx-3 were negatively correlated with TAC and IL-8 was positively correlated with the free T4 level, the ATPO antibodies titers, GPx-3 activity and negatively with serum TAC values. Conclusions. Systemic oxidative stress and inflammation are present in thyroid disorders, act in cluster and potentiate each other.The presence of autoimmune antibodies worsens the biological picture.