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<i>Ferulago nodosa</i> (L.) Boiss. (Apiaceae) is a species occurring in the Balkan-Tyrrhenian area. The object of the present study is Sicilian <i>F. nodosa</i> subsp. <i>geniculata</i> (Guss.) Troia & Raimondo, classified as an endemic <i>F. nodosa</i> subspecies. Aerial parts of this plant species were subjected to hydrodistillation to obtain an essential oil. A total of 93 compounds were identified with 2,3,6-trimethyl benzaldehyde (19.0%), spathulenol (9.0%), (<i>E</i>)-caryophyllene (5.4%), and caryophyllene oxide (5.4%) as the main components. The biological activities of <i>F. nodosa</i> essential oil were also investigated. This oil showed an interesting antioxidant potential in a 2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) test (IC₅₀ of 14.05 μg/mL). Additionally, hypoglycemic and antilipidemic effects were evaluated. Lipase enzyme was inhibited with an IC₅₀ value of 41.99 μg/mL. Obtained data demonstrated that <i>F. nodosa</i> could be considered a promising source of bioactive compounds useful for the treatment and management of obesity.