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[<b>Objectives</b>] In order to achieve safe and lightweight structural design,structural optimization is usually performed.[<b>Methods</b>] In the present research,a structural optimization platform is developed based on ISIGHT platform and finite element method. A parameterized model of the objective deep-water drilling ship is generated and the structural optimization on transverse structures is carried out in the proposed optimization platform. The plate thickness and the stiffener size are considered as discrete variable in the optimization platform.[<b>Results</b>] The structural weight of the transverse components of deep-water drilling ship can be reduced by 11% after the optimization.[<b>Conclusions</b>] This paper shows that the structural weight can be effectively reduced by the optimized design of strong frame structure.