Monitoring single-cell gene regulation under dynamically controllable conditions with integrated microfluidics and software

oleh: Matthias Kaiser, Florian Jug, Thomas Julou, Siddharth Deshpande, Thomas Pfohl, Olin K. Silander, Gene Myers, Erik van Nimwegen

Format: Article
Diterbitkan: Nature Portfolio 2018-01-01

Deskripsi

How gene regulatory pathways control cell fate decisions in single cells is not fully understood. Here the authors present an integrated dual-input microfluidic chip and a linked analysis software, enabling tracking of gene regulatory responses of single bacterial cells to changing conditions.