Simplified Synthesis of Isotopically Labeled 5,5-Dimethyl-pyrroline N-Oxide

oleh: Ronald P. Mason, Fabian Leinisch, Leesa J. Deterding, JinJie Jiang

Format: Article
Diterbitkan: MDPI AG 2011-10-01

Deskripsi

5,5-Dimethylpyrroline N-oxide (15N) and 5,5-di(trideuteromethyl)pyrroline N-oxide were synthesized from the respective isotopically labeled 2-nitropropane analogs obtained from the reaction of sodium nitrate with 2-halopropanes. This facile, straightforward process allows synthesizing isotopically labeled DMPO analogs in a 4-step reaction without special equipment.