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The present study aims to: (a) explain challenges experienced by midwives; (b) evaluate the working condition in midwifery working settings. This exploratory sequential mixed-methods study is conducted in three stages (qualitative, quantitative, and nominal group), in Tabriz and Ilam. A qualitative study will be carried out to explain challenges experienced by midwives and the subjects selected through purposive sampling; moreover, in-depth individual interviewing will be used for data collection. The quantitative phase will be used a cross-sectional approach for evaluating the working condition in midwifery working settings. Finally, using findings of the two phases and nominal group technique some strategies will be given to reduce challenges of the midwifery working settings. The results can be used to develop strategies for creating suitable working conditions. It is hoped that the strategy proposed in the current study could lead to improvements in midwives’ satisfaction and health care services.