Bridging non-overlapping reads illuminates high-order epistasis between distal protein sites in a GPCR
oleh: Justin I. Yoo, Patrick S. Daugherty, Michelle A. O’Malley
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-02-01 |
Deskripsi
Epistasis effects among amino acids at distal sites within binding pockets can have important impacts on protein fitness landscapes. Here the authors present BRIDGE, which matches non-overlapping sequence reads with their cognate DNA templates.