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The M. citrifolia, commonly called starvation fruit, plays an essential role in daily dietary intakes, as it contains several vitamins, phytochemicals, and electrolytes. These constituents have several biological activities that are anti-tumor, antibacterial, antiviral, antifungal, and play a role in the immune system. The silver nanoparticles (AgNPs) were synthesized using a more uncomplicated and fast means using the M. citrifolia fruit samples. The Silver ions (Ag+) readily get reduced to (Ag0) to perform M. Citrifolia AgNPs hence the fruit extracts of M. Citrifolia can be considered potential lowering agents. The preliminary confirmation was done qualitatively by change of color into brownish-black, and the color change was observed due to bio-reduction and the Surface Plasmon Resonance (SPR) vibration. It was established by the absorbance peak at 430 nm using UV–Visible spectral analysis. Scanning Electron microscopy (SEM) showed the particle size ranging from 12 to 26 nm. Fourier-transform infrared spectroscopy (FTIR) confirmed the presence of the functional groups from synthesized M. citrifolia AgNPs. The biochemical studies were supported by the effect of antioxidant and anticancer properties of M. citrifolia AgNPs. The pathological changes were studied using hematoxylin, and Eosin staining in Albino mice, which was no tumor (Ehrlich ascites carcinoma) cell invasion exhibited in Fluorouracil treated group. The present investigation proves that the M. citrifolia fruit extract derived AgNPs is a promising antioxidant agent to treat liver cancer.