R-loop proximity proteomics identifies a role of DDX41 in transcription-associated genomic instability
oleh: Thorsten Mosler, Francesca Conte, Gabriel M. C. Longo, Ivan Mikicic, Nastasja Kreim, Martin M. Möckel, Giuseppe Petrosino, Johanna Flach, Joan Barau, Brian Luke, Vassilis Roukos, Petra Beli
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-12-01 |
Deskripsi
Transcription can pose a threat to genomic instability through the formation of R-loops, which are RNA–DNA hybrids with a displaced non-template DNA strand. Here the authors mapped the R-loop proximal proteome in human cells and identified a role of the tumor suppressor DDX41 in opposing R-loop and double strand DNA break accumulation in gene promoters.