Pyrin-only protein 2 limits inflammation but improves protection against bacteria
oleh: Sivakumar Periasamy, Kristen A. Porter, Maninjay K. Atianand, Hongnga T. Le, Sarah Earley, Ellen B. Duffy, Matthew C. Haller, Heather Chin, Jonathan A. Harton
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-06-01 |
Deskripsi
Pyrin-only proteins (POPs) are primate-specific negative regulators of inflammasome activation. Here the authors generate transgenic mice expressing POP2 under the control of the human promoter, and show that POP2 is important for balancing antibacterial inflammatory responsesin vivo.