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ABSTRACT: The purpose of study was to differentiate ischemic central retinal vein occlusion from non ischemic central retinal vein occlusion using homocysteine level as a biochemical marker during early stage of the disease. METHOD: Fasting plasma homocysteine level was measured in 50 patients with unilateral ischemic central retinal vein occlusion and compared with a total of 50 age matched patients with non ischemic central retinal vein occlusion patients and 50 age matched healthy control subjects. RESULTS: Homocysteine level was found significantly increased in ischemic vein occlusion(27.1mmol/l)as compared to non ischemic vein occlusion (14.6 mmol/l) and control (12.8mmol/l) subject.(P< .05)