PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma
oleh: Tianrun Liu, Wenjuan Ma, Haineng Xu, Menggui Huang, Duo Zhang, Zhenqiang He, Lin Zhang, Steven Brem, Donald M. O’Rourke, Yanqing Gong, Yonggao Mou, Zhenfeng Zhang, Yi Fan
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-08-01 |
Deskripsi
Resistance to anti-angiogenic therapies often occurs in patients. Here, the authors demonstrate the role of PDGF signaling in GBM resistance to anti-VEGF treatment via a mechanism that involves endothelial-mesenchymal transformation and transcriptional regulation of VEGFR-2.