Experimental strategies to improve drug-target identification in mass spectrometry-based thermal stability assays
oleh: Clifford G. Phaneuf, Konstantin Aizikov, Dmitry Grinfeld, Arne Kreutzmann, Daniel Mourad, Oliver Lange, Daniel Dai, Bailin Zhang, Alexei Belenky, Alexander A. Makarov, Alexander R. Ivanov
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-04-01 |
Deskripsi
Mass spectrometry-based thermal stability assays (MS-TSA) are a promising approach to characterize protein-ligand interaction, and several strategies have been recently developed to improve their performance. Here, the authors combine three recent strategies to qualitatively and quantitatively improve aspects of MS-TSA.