A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage
oleh: Chao Shan, Antonio E. Muruato, Brett W. Jagger, Justin Richner, Bruno T. D. Nunes, Daniele B. A. Medeiros, Xuping Xie, Jannyce G. C. Nunes, Kaitlyn M. Morabito, Wing-Pui Kong, Theodore C. Pierson, Alan D. Barrett, Scott C. Weaver, Shannan L. Rossi, Pedro F. C. Vasconcelos, Barney S. Graham, Michael S. Diamond, Pei-Yong Shi
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2017-09-01 |
Deskripsi
Zika virus infection can result in congenital disorders and cause disease in adults, and there is currently no approved vaccine. Here Shan et al. show that a single dose of a live-attenuated Zika vaccine prevents infection, testis damage and transmission to the fetus during pregnancy in different animal models.