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<p>Alzheimer's disease (AD) is a degenerative disease of the central nervous system, and its pathogenesis is complex. Animal models play an important role in study on pathogenesis and treatment of AD. This paper summarized methods of building models, observation on animal models and evaluation index in recent years, so as to provide related evidence for basic and clinical research in future.</p><p> </p><p><strong>DOI: </strong>10.3969/j.issn.1672-6731.2015.08.003</p>