Comprehensive profiling of the ligand binding landscapes of duplexed aptamer families reveals widespread induced fit
oleh: Jeffrey D. Munzar, Andy Ng, David Juncker
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-01-01 |
Deskripsi
Duplexed aptamers are a common biosensor format; however, how complementary strand sequence, length, and position modulate ligand binding is not well understood. Here, the authors introduce ACE-Scan to comprehensively map binding landscapes, uncovering hotspots of enhanced binding by induced fit.