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Objective. To determine the psychometric properties of Goldberg’s General Health Questionnaire –GHQ-28– in a sample of Mexican primary caregivers of cancer patients. Method: Two hundred and seventy six caregivers participated in this protocol, 205 of which were women (74.3%) and 71 were men (25.7%). Participants answered the GHQ-28 and the Beck Depression Inventory (BDI) concurrently. Results. The internal consistency of the overall scale showed a satisfactory index (α = 0.91). The Cronbach alphas of the subscale had a value of α = .86, α = .76, explaining the 53.42% of the variance. The correlation validity by BDI showed significant outcomes (Pearson r= 0.723 - 0.427, p <0.05). Conclusions. The relevance of the outcomes is that this is a population that can show damages in the overall health throughout the process of care for cancer patients.