Interleukin 2 modulates thymic-derived regulatory T cell epigenetic landscape
oleh: Laurent Chorro, Masako Suzuki, Shu Shien Chin, Tere M. Williams, Erik L. Snapp, Livia Odagiu, Nathalie Labrecque, Grégoire Lauvau
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-12-01 |
Deskripsi
Regulatory T (Treg) cells are developed in the thymus, and are essential for suppressing detrimental autoimmunity. Here the authors show, using mice with dampened interleukin 2 (IL-2) signaling, that IL-2 helps position the pioneer factor SATB1 to control genome-wide chromatin accessibility to facilitate Treg cell lineage commitment in the thymus.