Nanotherapy targeting NF-κB attenuates acute pain after joint injury
oleh: Huimin Yan, Xin Duan, Kelsey H. Collins, Luke E. Springer, Farshid Guilak, Samuel A. Wickline, M. Farooq Rai, Hua Pan, Christine Pham
| Format: | Article |
|---|---|
| Diterbitkan: | Andover House Inc. 2019-01-01 |
Deskripsi
<img src="https://s3.amazonaws.com/production.scholastica/article/6949/original/739500_graphical_abstract.jpg?1547322156"> Inflammation after joint injury leads to joint responses that result in eventual osteoarthritis development. Blockade of inflammation, by suppressing NF-κB expression, has been shown to reduce joint injury-induced chondrocyte apoptosis and reactive synovitis in vivo. Herein, we demonstrate that the suppression of NF-κB p65 expression also significantly mitigates the acute pain sensitivity induced by mechanical injury to the joint. These results suggest that early intervention with anti-NF-κB nanotherapy mitigates both structural and pain-related outcomes, which in turn may impact the progression of post-traumatic osteoarthritis. [READ ARTICLE](https://precisionnanomedicine.com/article/6949)