Identification of predictors of drug sensitivity using patient-derived models of esophageal squamous cell carcinoma
oleh: Dan Su, Dadong Zhang, Jiaoyue Jin, Lisha Ying, Miao Han, Kaiyan Chen, Bin Li, Junzhou Wu, Zhenghua Xie, Fanrong Zhang, Yihui Lin, Guoping Cheng, Jing-Yu Li, Minran Huang, Jinchao Wang, Kailai Wang, Jianjun Zhang, Fugen Li, Lei Xiong, Andrew Futreal, Weimin Mao
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-11-01 |
Deskripsi
Predicting the drug response of patients with cancer is crucial for implementing targeted therapy. Here, Su et al. make patient-derived cell lines and perform targeted sequencing and RNA-seq to identify CDKN2A/2B loss as a predictor of response to CDK4/6 inhibitors in esophageal squamous cell carcinoma.