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Objective: Momen Tonekabani is one of the most famous physicians in the history of Iranian herbal pharmacology. He wrote a comprehensive book of single and compound drugs with the aim of correcting the book Ekhtiarat-e-badiee . This book is an example of the pharmacology books in the Safavide era. Infertility is a complex life crisis and a psychological threat. Many studies have likened the psychological consequences of infertility to public grief reactions.   Methods: This review study, using a library method, focuses on the book Tohfat al-Momenin for collecting data. In this regard, effective materia medica in infertility treatment are investigated.  Results: We found 396 materia medica, each of which had a direct and indirect effect on infertility. They could be consumed in the form of incense, ointment, herbal bath, gilding, vaginal suppository, half-boiled, rectal suppository, and oral.   Conclusion: The list of materia medica presented in this study can be tested in experimental and clinical studies, and If proven to be effective, can be used in infertility treatment.