Disease-associated missense mutations in GluN2B subunit alter NMDA receptor ligand binding and ion channel properties
oleh: Laura Fedele, Joseph Newcombe, Maya Topf, Alasdair Gibb, Robert J. Harvey, Trevor G. Smart
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-03-01 |
Deskripsi
N-methyl-d-aspartate-receptors (NMDARs) are glutamate receptors critical for synaptic transmission, plasticity, and cognition. Here, the authors look at four neurodevelopmental disease-related mutations of NMDAR, gaining insight into binding of Mg2+ and mechanism of memantine, an NMDAR antagonist.