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A senataxin-associated exonuclease SAN1 is required for resistance to DNA interstrand cross-links
oleh: Alex M. Andrews, Heather J. McCartney, Tim M. Errington, Alan D. D’Andrea, Ian G. Macara
Format: | Article |
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Diterbitkan: | Nature Portfolio 2018-07-01 |
Deskripsi
When DNA interstrand cross-links damage occurs, it causes disruption of replication and transcription. Here the authors identify FAM120B/SAN1, a 5′ exonuclease involved in the repair process of Interstrand Crosslinks independently of the Fanconi Anemia pathway.