Using single nucleotide variations in single-cell RNA-seq to identify subpopulations and genotype-phenotype linkage
oleh: Olivier Poirion, Xun Zhu, Travers Ching, Lana X. Garmire
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-11-01 |
Deskripsi
Identification of cell subpopulations using transcript abundance is noisy. Here, the authors developed a linear modeling framework, SSrGE, which utilizes effective and expressed nucleotide variations from single-cell RNA-seq to identify tumor subpopulations.