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The paper deals with a theoretical study on blood flow in a stenosed segment of an artery, when blood is mixed with nano-particles. Blood is treated here as a couple stress fluid. Stenosis is known to impede blood flow and to be the cause of different cardiac diseases. Since the arterial wall is weakened due to arterial stenosis, it may lead to dilatation /aneurysm. The homotopy perturbation technique is employed to determine the solution to the problem for the case of mild stenosis. Analytical expressions for velocity, shear stress at the wall, pressure drop, and flow resistance are derived. The impact of different physical constants on the wall shear stress and impedance of the fluid is examined by numerical simulation. Streamline patterns of the nanofluid are investigated for different situations.