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Acute appendicitis is the most common non-traumatic emergency surgical pathology, and duplication of the appendix is a rare congenital anomaly usually detected incidentally during laparotomy. Since Picoli first described appendix duplex in a female patient who presented with associated anomalies, few other cases have been reported. In this study, we aimed to present a case of appendix duplication detected in a 56-year-old female renal transplant patient undergoing surgery for acute appendicitis. Surgical management of double appendix is of practical importance to avoid serious medical and legal consequences.