High precision FRET studies reveal reversible transitions in nucleosomes between microseconds and minutes

oleh: Alexander Gansen, Suren Felekyan, Ralf Kühnemuth, Kathrin Lehmann, Katalin Tóth, Claus A. M. Seidel, Jörg Langowski

Format: Article
Diterbitkan: Nature Portfolio 2018-11-01

Deskripsi

Nucleosomes compact the genome and regulate access to specific DNA sequences. Here the authors employ single-molecule FRET studies to characterize nucleosome dynamics at different salt concentrations and dissect nucleosome disassembly into elementary steps.