CD109 Restrains Activation of Cutaneous IL-17-Producing γδ T Cells by Commensal Microbiota

oleh: Hualin Zhang, Giustino Carnevale, Barbara Polese, Melissa Simard, Bavanitha Thurairajah, Nargis Khan, Maria E. Gentile, Ghislaine Fontes, Donald C. Vinh, Roxane Pouliot, Irah L. King

Format: Article
Diterbitkan: Elsevier 2019-10-01

Deskripsi

Summary: Interleukin-17-producing γδ T (γδ17) cells play a central role in protective and pathogenic immune responses. However, the tissue-specific mechanisms that control the activation of these innate lymphocytes are not known. Here, we demonstrate that CD109, a glycosylphosphatidylinositol (GPI)-anchored protein highly expressed by keratinocytes, is an important regulator of skin homeostasis and γδ17 cell activation. Genetic deletion of CD109 results in spontaneous epidermal hyperplasia, aberrant accumulation of dermal-derived γδ17 cells, and enhanced susceptibility to psoriasiform inflammation. In this context, γδ17 activation requires interleukin (IL)-23 signals and is reversed by transient depletion of the skin microbiota. Mechanistically, CD109 restrains γδ17 cell activation in a cell-extrinsic manner by fortifying skin barrier integrity. Collectively, our data provide insight into the regulation of the skin IL-23/IL-17 immune axis and how homeostasis is maintained at this important barrier site. : Zhang et al. demonstrate that CD109 acts in a skin-specific and cell-extrinsic manner to regulate interleukin (IL)-17 production by cutaneous γδ T cells. Genetic loss of CD109 results in spontaneous skin inflammation and an enhanced susceptibility to psoriasiform inflammation, a phenotype that can be reversed with topical application of antibiotics. Keywords: skin, CD109, IL-17, gamma delta T cells, barrier tissue, immunity, microbiota, psoriasis