Copper-Catalyzed N-Arylation of Amides Using (S)-N-Methylpyrrolidine-2-carboxylate as the Ligand
oleh: Dong-Sheng Ma, Hua Zhang, Wei Wang, Lijuan Liu, Chaoyu Wang
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2010-03-01 |
Deskripsi
(S)-N-methylpyrrolidine-2-carboxylate, a derivative of natural L-proline, was found to be an efficient ligand for the copper-catalyzed Goldberg-type N-arylation of amides with aryl halides under mild conditions. A variety of N-arylamides were synthesized in good to high yields.