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Introduction: Osteosarcoma (OS) is primary malignant bone tumor in which mesenchymal cell produce osteoid. OS of jawbones is uncommon, representing 4-8% of all OS. Case Report: This paper reports the case of a- 29 year-old female with an OS in mandibular first molar as exophitic lesion with smooth surface during 1 year. Based on the patient's symptoms, differential diagnosis was lymphoma and malignant meshenshymal tumors. Exci-sional biopsy was done and histopatholigic feature proved to be OS. Conclusion: Postoperatively, the patient was referred to the oncology department of Tehran Imam Khomeini hospital for further evaluation and treatment.