Activation of NIX-mediated mitophagy by an interferon regulatory factor homologue of human herpesvirus
oleh: Mai Tram Vo, Barbara J. Smith, John Nicholas, Young Bong Choi
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-07-01 |
Deskripsi
Impaired removal of damaged mitochondria by mitophagy can activate innate immune signaling, but impact on virus replication remains unclear. Here the authors show that viral IRF-1 of human herpesvirus 8 activates mitophagy via interaction with the mitophagy receptor NIX and that vIRF-1 induced mitophagy supports productive infection.