Cytotoxic Activity of Inositol Angelates and Tirucallane-Type Alkaloids from <i>Amoora Dasyclada</i>
oleh: Sheng-Xiang Yang, Cheng-Gang Song, Yi Kuang, Bing Liu, Yan-Xin Zhang, Ming-Zhe Zhang, Chun-Ying Zhang, Gang Ding, Jian-Chun Qin
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2020-03-01 |
Deskripsi
Three new inositol angelate compounds (<b>1−3</b>) and two new tirucallane-type alkaloids (<b>4</b> and <b>5</b>) were isolated from the <i>Amoora dasyclada</i>, and their structures were established mainly by means of combination of 1D and 2D nuclear magnetic resonance and HR-ESI-MS. Based on cytotoxicity testing, compounds <b>4</b> and <b>5</b> exhibited significant cytotoxic activity against human cancer cell line HepG2 with IC<sub>50</sub> value at 8.4 and 13.2 μM. In addition, compounds <b>4</b> and <b>5</b> also showed remarkable growth inhibitory activity to <i>Artemia salina</i> larvae.