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Primary bone lymphoma is a rare type of non-Hodgkin's lymphoma. It commonly arises from long bones such as the femur in the appendicular skeleton. The authors present a case of primary bone lymphoma of the clavicle, an uncommon location for this pathology, presenting as a painful supraclavicular lump in a 76-year-old woman. Magnetic resonance imaging and ultrasound examinations showed the typical feature of preservation of the bony cortex, and PET-CT revealed no alternative primary site of malignancy. This case highlights the importance of considering typical imaging characteristics of a lesion, even if it presents in an unusual site, as well as the value of completion imaging in clinical practice to secure a diagnosis.