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Abstract Eight new diarylheptanoids, coriandralpinins A–H (1–8), were isolated from the rhizomes of Alpinia coriandriodora, an edible plant of the ginger family. Their structures, including the absolute configurations, were established by extensive spectroscopic analysis and ECD calculations. Compounds 1–8 have a 1,5-O-bridged diarylheptanoid structure featuring polyoxygenated aryl units. When evaluated for intracellular antioxidant activity using t-BHP stressed RAW264.7 macrophages, all these compounds scavenged reactive oxygen species (ROS) in a concentration-dependent manner. Compounds 3 and 5 also showed inhibitory activity against NO release in LPS-induced RAW 264.7 cells. Six known flavonols, 7,4′-di-O-methylkaempferol, 7-O-methylquercetin, 7,4′-di-O-methylquercetin, 7,3′,4′-tri-O- methylquercetin, kaempferol 3-O-β-d-(6-O-α-l-rhamnopyranosyl)glucopyranoside, and 3-O-β-d-glucopyranuronosylquercetin were also isolated and characterized from the rhizomes.