PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex
oleh: Stephanie Link, Ramona M. M. Spitzer, Maryam Sana, Mario Torrado, Moritz C. Völker-Albert, Eva C. Keilhauer, Thomas Burgold, Sebastian Pünzeler, Jason K. K. Low, Ida Lindström, Andrea Nist, Catherine Regnard, Thorsten Stiewe, Brian Hendrich, Axel Imhof, Matthias Mann, Joel P. Mackay, Marek Bartkuhn, Sandra B. Hake
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-10-01 |
Deskripsi
PWWP2A is a chromatin-binding transcriptional regulator that mediates mitosis-progression. Here, the authors provide evidence that PWWP2A directly interacts with H2A.Z nucleosomes, DNA and H3K36me3, binds to an MTA1-specific subcomplex of the NuRD complex (M1HR) and promotes changes to histone acetylation.