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Purpose: The aim of this study was to evaluate the effects of dexmedetomidine on the use of laryngeal mask airway and the cobra perilaryngeal airway in children.Materials and Methods: The medical records of 112 children who received sevoflurane alone and sevoflurane plus dexmedetomidine (loading dose 1 µg/kg + infusion 0.5 µg/kg/h) during elective inguinal region surgery with LMA or CobraPLA were retrospectively reviewed: Group LMA, Group CobraPLA, Group Dex+LMA and Group Dex+CobraPLA. Patients’ demographic data, hemodynamic parameters, the number of trials and time to achieve an effective airway, the end-tidal sevoflurane (ETSevo) concentration, plateau pressure (P plateau), peak inspiratory pressure (PIP), end-tidal carbondioxide (ETCO2) values, and complications were noted.Results: Demographic and anesthetic data, hemodynamic parameters, and complications were similar between the groups. The number of attempts, the time for insertions, P plateau, and PIP were statistically higher in the LMA group compared to other groups. ETSevo concentrations were lower in the Dex+CobraPLA group compared to LMA and CobraPLA group. The ETCO2 measurements were higher in the CobraPLA and Dex+CobraPLA groups compared to other groups. Conclusion: Dexmedetomidine reduced airway pressures and ETSevo concentrations without side effects in the children with SADs.