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On the Interplay between Entropy and Robustness of Gene Regulatory Networks
oleh: Bor-Sen Chen, Cheng-Wei Li
Format: | Article |
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Diterbitkan: | MDPI AG 2010-05-01 |
Deskripsi
The interplay between entropy and robustness of gene network is a core mechanism of systems biology. The entropy is a measure of randomness or disorder of a physical system due to random parameter fluctuation and environmental noises in gene regulatory networks. The robustness of a gene regulatory network, which can be measured as the ability to tolerate the random parameter fluctuation and to attenuate the effect of environmental noise, will be discussed from the robust H∞ stabilization and filtering perspective. In this review, we will also discuss their balancing roles in evolution and potential applications in systems and synthetic biology.