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MicroRNA miR-274-5p Suppresses <i>Found-in-Neurons</i> Associated with Melanotic Mass Formation and Developmental Growth in <i>Drosophila</i>
oleh: Hee Kyung Kim, Chae Jeong Kim, Daegyu Jang, Do-Hwan Lim
Format: | Article |
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Diterbitkan: | MDPI AG 2023-08-01 |
Deskripsi
The hematopoietic system plays a crucial role in immune defense response and normal development, and it is regulated by various factors from other tissues. The dysregulation of hematopoiesis is associated with melanotic mass formation; however, the molecular mechanisms underlying this process are poorly understood. Here, we observed that the overexpression of <i>miR-274</i> in the fat body resulted in the formation of melanotic masses. Moreover, abnormal activation of the JNK and JAK/STAT signaling pathways was linked to these consequences. In addition to this defect, <i>miR-274</i> overexpression in the larval fat body decreased the total tissue size, leading to a reduction in body weight. miR-274-5p was found to directly suppress the expression of <i>found-in-neurons</i> (<i>fne</i>), which encodes an RNA-binding protein. Similar to the effects of <i>miR-274</i> overexpression, <i>fne</i> depletion led to melanotic mass formation and growth reduction. Collectively, miR-274 plays a regulatory role in the <i>fne</i>–JNK signaling axis in melanotic mass formation and growth control.