Poly(ADP) ribose polymerase promotes DNA polymerase theta-mediated end joining by activation of end resection
oleh: Megan E. Luedeman, Susanna Stroik, Wanjuan Feng, Adam J. Luthman, Gaorav P. Gupta, Dale A. Ramsden
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-08-01 |
Deskripsi
Poly(ADP) ribose polymerase (PARP) activity promotes, but is not required for, chromosome break repair by polymerase theta-mediated end joining (TMEJ). PARP activity promotes TMEJ by stimulating resection, a process that controls pathway choice.