Hasil Pencarian - Warren D Hirst

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  1. 1
    Mitochondrial Dysfunction in Astrocytes: A Role in Parkinson’s Disease?

    Mitochondrial Dysfunction in Astrocytes: A Role in Parkinson’s Disease? oleh Collin M. Bantle, Warren D. Hirst, Andreas Weihofen, Evgeny Shlevkov

    Diterbitkan 2021-01-01
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  2. 2
    RIT2 regulates autophagy lysosomal pathway induction and protects against α-synuclein pathology in a cellular model of Parkinson's disease

    RIT2 regulates autophagy lysosomal pathway induction and protects against α-synuclein pathology in a cellular model of Parkinson's disease oleh Andy Y.L. Gao, Daniel R. Montagna, Warren D. Hirst, Paul A. Temkin

    Diterbitkan 2024-09-01
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  3. 3
    Quantitative Measurements of LRRK2 in Human Cerebrospinal Fluid Demonstrates Increased Levels in G2019S Patients

    Quantitative Measurements of LRRK2 in Human Cerebrospinal Fluid Demonstrates Increased Levels in G2019S Patients oleh Omar S. Mabrouk, Siwei Chen, Amanda L. Edwards, Minhua Yang, Warren D. Hirst, Danielle L. Graham

    Diterbitkan 2020-05-01
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  4. 4
    Tool compounds robustly increase turnover of an artificial substrate by glucocerebrosidase in human brain lysates.

    Tool compounds robustly increase turnover of an artificial substrate by glucocerebrosidase in human brain lysates. oleh Zdenek Berger, Sarah Perkins, Claude Ambroise, Christine Oborski, Matthew Calabrese, Stephen Noell, David Riddell, Warren D Hirst

    Diterbitkan 2015-01-01
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  5. 5
    Perspective on the current state of the LRRK2 field

    Perspective on the current state of the LRRK2 field oleh Jean-Marc Taymans, Matt Fell, Tim Greenamyre, Warren D. Hirst, Adamantios Mamais, Shalini Padmanabhan, Inga Peter, Hardy Rideout, Avner Thaler

    Diterbitkan 2023-07-01
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  6. 6
    Human A53T α-synuclein causes reversible deficits in mitochondrial function and dynamics in primary mouse cortical neurons.

    Human A53T α-synuclein causes reversible deficits in mitochondrial function and dynamics in primary mouse cortical neurons. oleh Li Li, Sashi Nadanaciva, Zdenek Berger, Wei Shen, Katrina Paumier, Joel Schwartz, Kewa Mou, Paula Loos, Anthony J Milici, John Dunlop, Warren D Hirst

    Diterbitkan 2013-01-01
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  7. 7
    Identification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motif.

    Identification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motif. oleh Pooja P Pungaliya, Yuchen Bai, Kerri Lipinski, Vasanti S Anand, Saurabh Sen, Eugene L Brown, Brian Bates, Peter H Reinhart, Andrew B West, Warren D Hirst, Steven P Braithwaite

    Diterbitkan 2010-10-01
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  8. 8
    A rapid, semi-quantitative assay to screen for modulators of alpha-synuclein oligomerization ex vivo

    A rapid, semi-quantitative assay to screen for modulators of alpha-synuclein oligomerization ex vivo oleh Marion eDelenclos, Teodora eTrendafilova, Daryl R Jones, Simon eMoussaud, Ann Marie eBaine, Mei eYue, Warren D Hirst, Pamela J McLean, Pamela J McLean

    Diterbitkan 2016-01-01
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  9. 9
    Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease

    Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease oleh Steven P. Braithwaite, Ralf S. Schmid, Dong Ning He, Mei-Li A. Sung, Seongeon Cho, Lynn Resnick, Michael M. Monaghan, Warren D. Hirst, Christian Essrich, Peter H. Reinhart, Donald C. Lo

    Diterbitkan 2010-09-01
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  10. 10
    Transient exposure to rotenone causes degeneration and progressive parkinsonian motor deficits, neuroinflammation, and synucleinopathy

    Transient exposure to rotenone causes degeneration and progressive parkinsonian motor deficits, neuroinflammation, and synucleinopathy oleh Amber D. Van Laar, Katherine R. Webb, Matthew T. Keeney, Victor S. Van Laar, Alevtina Zharikov, Edward A. Burton, Teresa G. Hastings, Kelly E. Glajch, Warren D. Hirst, J. Timothy Greenamyre, Emily M. Rocha

    Diterbitkan 2023-08-01
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  11. 11
    The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson’s Disease

    The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson’s Disease oleh Hardy J. Rideout, Marie-Christine Chartier-Harlin, Marie-Christine Chartier-Harlin, Matthew J. Fell, Warren D. Hirst, Sarah Huntwork-Rodriguez, Cheryl E. G. Leyns, Omar S. Mabrouk, Jean-Marc Taymans, Jean-Marc Taymans

    Diterbitkan 2020-08-01
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  12. 12
    Discovery of small-molecule positive allosteric modulators of Parkin E3 ligase

    Discovery of small-molecule positive allosteric modulators of Parkin E3 ligase oleh Evgeny Shlevkov, Paramasivam Murugan, Dan Montagna, Eric Stefan, Adelajda Hadzipasic, James S. Harvey, P. Rajesh Kumar, Sonya Entova, Nupur Bansal, Shari Bickford, Lai-Yee Wong, Warren D. Hirst, Andreas Weihofen, Laura F. Silvian

    Diterbitkan 2022-01-01
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  13. 13
    Behavioral characterization of A53T mice reveals early and late stage deficits related to Parkinson's disease.

    Behavioral characterization of A53T mice reveals early and late stage deficits related to Parkinson's disease. oleh Katrina L Paumier, Stacey J Sukoff Rizzo, Zdenek Berger, Yi Chen, Cathleen Gonzales, Edward Kaftan, Li Li, Susan Lotarski, Michael Monaghan, Wei Shen, Polina Stolyar, Dmytro Vasilyev, Margaret Zaleska, Warren D Hirst, John Dunlop

    Diterbitkan 2013-01-01
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  14. 14
    Activation of parkin by a molecular glue

    Activation of parkin by a molecular glue oleh Véronique Sauvé, Eric Stefan, Nathalie Croteau, Thomas Goiran, Rayan Fakih, Nupur Bansal, Adelajda Hadzipasic, Jing Fang, Paramasivam Murugan, Shimin Chen, Edward A. Fon, Warren D. Hirst, Laura F. Silvian, Jean-François Trempe, Kalle Gehring

    Diterbitkan 2024-09-01
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  15. 15
    Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models

    Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models oleh Andreas Weihofen, YuTing Liu, Joseph W. Arndt, Christian Huy, Chao Quan, Benjamin A. Smith, Jean-Luc Baeriswyl, Nicole Cavegn, Luzia Senn, Lihe Su, Galina Marsh, Pavan K. Auluck, Fabio Montrasio, Roger M. Nitsch, Warren D. Hirst, Jesse M. Cedarbaum, R. Blake Pepinsky, Jan Grimm, Paul H. Weinreb

    Diterbitkan 2019-04-01
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  16. 16
    Beta2-adrenoreceptor agonist clenbuterol produces transient decreases in alpha-synuclein mRNA but no long-term reduction in protein

    Beta2-adrenoreceptor agonist clenbuterol produces transient decreases in alpha-synuclein mRNA but no long-term reduction in protein oleh Joseph R. Patterson, Warren D. Hirst, Jacob W. Howe, Christopher P. Russell, Allyson Cole-Strauss, Christopher J. Kemp, Megan F. Duffy, Jared Lamp, Andrew Umstead, Michael Kubik, Anna C. Stoll, Irving E. Vega, Kathy Steece-Collier, Yi Chen, Anne C. Campbell, Catherine L. Nezich, Kelly E. Glajch, Caryl E. Sortwell

    Diterbitkan 2022-05-01
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  17. 17
    Decreased glucocerebrosidase activity and substrate accumulation of glycosphingolipids in a novel GBA1 D409V knock-in mouse model.

    Decreased glucocerebrosidase activity and substrate accumulation of glycosphingolipids in a novel GBA1 D409V knock-in mouse model. oleh Nicole K Polinski, Terina N Martinez, Alexander Gorodinsky, Ralph Gareus, Michael Sasner, Mark Herberth, Robert Switzer, Syed O Ahmad, Mali Cosden, Monika Kandebo, Robert E Drolet, Peter D Buckett, Weisong Shan, Yi Chen, Lee J Pellegrino, Gregory D Ellsworth, Leo B Dungan, Warren D Hirst, Sean W Clark, Kuldip D Dave

    Diterbitkan 2021-01-01
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  18. 18
    Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease

    Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease oleh Luis M. A. Oliveira, Thomas Gasser, Robert Edwards, Markus Zweckstetter, Ronald Melki, Leonidas Stefanis, Hilal A. Lashuel, David Sulzer, Kostas Vekrellis, Glenda M. Halliday, Julianna J. Tomlinson, Michael Schlossmacher, Poul Henning Jensen, Julia Schulze-Hentrich, Olaf Riess, Warren D. Hirst, Omar El-Agnaf, Brit Mollenhauer, Peter Lansbury, Tiago F. Outeiro

    Diterbitkan 2021-07-01
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  19. 19
    Dose-dependent reduction of somatic expansions but not Htt aggregates by di-valent siRNA-mediated silencing of MSH3 in HdhQ111 mice

    Dose-dependent reduction of somatic expansions but not Htt aggregates by di-valent siRNA-mediated silencing of MSH3 in HdhQ111 mice oleh Rachelle Driscoll, Lucas Hampton, Neeta A. Abraham, J. Douglas Larigan, Nadine F. Joseph, Juan C. Hernandez-Vega, Sarah Geisler, Fu-Chia Yang, Matthew Deninger, David T. Tran, Natasha Khatri, Bruno M. D. C. Godinho, Garth A. Kinberger, Daniel R. Montagna, Warren D. Hirst, Catherine L. Guardado, Kelly E. Glajch, H. Moore Arnold, Corrie L. Gallant-Behm, Andreas Weihofen

    Diterbitkan 2024-01-01
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