Hasil Pencarian - Todd M. Pitts

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  1. 1
    Modulating Enzyme Function via Dynamic Allostery within Biliverdin Reductase B

    Modulating Enzyme Function via Dynamic Allostery within Biliverdin Reductase B oleh Jasmina S. Redzic, Michael R. Duff, Ashley Blue, Todd M. Pitts, Pratul Agarwal, Elan Zohar Eisenmesser

    Diterbitkan 2021-05-01
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  2. 2
    Utilization of quantitative in vivo pharmacology approaches to assess combination effects of everolimus and irinotecan in mouse xenograft models of colorectal cancer.

    Utilization of quantitative in vivo pharmacology approaches to assess combination effects of everolimus and irinotecan in mouse xenograft models of colorectal cancer. oleh Erica L Bradshaw-Pierce, Todd M Pitts, Gillian Kulikowski, Heather Selby, Andrea L Merz, Daniel L Gustafson, Natalie J Serkova, S Gail Eckhardt, Colin D Weekes

    Diterbitkan 2013-01-01
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  3. 3
    Efficacy and Molecular Mechanisms of Differentiated Response to the Aurora and Angiogenic Kinase Inhibitor ENMD-2076 in Preclinical Models of p53-Mutated Triple-Negative Breast Cancer

    Efficacy and Molecular Mechanisms of Differentiated Response to the Aurora and Angiogenic Kinase Inhibitor ENMD-2076 in Preclinical Models of p53-Mutated Triple-Negative Breast Can... oleh Anastasia A. Ionkina, John J. Tentler, Jihye Kim, Anna Capasso, Todd M. Pitts, Karen A. Ryall, Rebekah R. Howison, Peter Kabos, Carol A. Sartorius, Aik Choon Tan, S. Gail Eckhardt, Jennifer R. Diamond

    Diterbitkan 2017-05-01
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  4. 4
    Overcoming doxorubicin resistance in triple-negative breast cancer using the class I-targeting HDAC inhibitor bocodepsin/OKI-179 to promote apoptosis

    Overcoming doxorubicin resistance in triple-negative breast cancer using the class I-targeting HDAC inhibitor bocodepsin/OKI-179 to promote apoptosis oleh Stephen G. Smoots, Anna R. Schreiber, Marilyn M. Jackson, Stacey M. Bagby, Adrian T A. Dominguez, Evan D. Dus, Cameron A. Binns, Morgan MacBeth, Phaedra A. Whitty, Jennifer R. Diamond, Todd M. Pitts

    Diterbitkan 2024-03-01
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  5. 5
    Evaluation of the efficacy of dasatinib, a Src/Abl inhibitor, in colorectal cancer cell lines and explant mouse model.

    Evaluation of the efficacy of dasatinib, a Src/Abl inhibitor, in colorectal cancer cell lines and explant mouse model. oleh Aaron J Scott, Eun-Kee Song, Stacey Bagby, Alicia Purkey, Martin McCarter, Csaba Gajdos, Kevin S Quackenbush, Benjamin Cross, Todd M Pitts, Aik Choon Tan, S Gail Eckhardt, Hubert Fenton, John Arcaroli, Wells A Messersmith

    Diterbitkan 2017-01-01
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  6. 6
    Combined inhibition of MEK and Aurora A kinase in KRAS/PIK3CA double-mutant colorectal cancer models

    Combined inhibition of MEK and Aurora A kinase in KRAS/PIK3CA double-mutant colorectal cancer models oleh S. Lindsey eDavis, S. Lindsey eDavis, Kelli M. Robertson, Todd M. Pitts, Todd M. Pitts, John J. Tentler, John J. Tentler, Erica L. Bradshaw-Pierce, Erica L. Bradshaw-Pierce, Erica L. Bradshaw-Pierce, Peter J. Klauck, Stacey M. Bagby, Stephanie L. Hyatt, Heather M. Selby, Anna eSpreafico, Jeffrey A Ecsedy, John J. Arcaroli, John J. Arcaroli, Wells A. Messersmith, Wells A. Messersmith, Aik Choon eTan, Aik Choon eTan, S. Gail eEckhardt, S. Gail eEckhardt

    Diterbitkan 2015-06-01
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  7. 7
    WEE1 Inhibition in Combination With Targeted Agents and Standard Chemotherapy in Preclinical Models of Pancreatic Ductal Adenocarcinoma

    WEE1 Inhibition in Combination With Targeted Agents and Standard Chemotherapy in Preclinical Models of Pancreatic Ductal Adenocarcinoma oleh Sarah J. Hartman, Stacey M. Bagby, Betelehem W. Yacob, Dennis M. Simmons, Morgan MacBeth, Christopher H. Lieu, S. Lindsey Davis, Alexis D. Leal, John J. Tentler, Jennifer R. Diamond, S. Gail Eckhardt, Wells A. Messersmith, Todd M. Pitts

    Diterbitkan 2021-03-01
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  8. 8
    RX-5902, a novel β-catenin modulator, potentiates the efficacy of immune checkpoint inhibitors in preclinical models of triple-negative breast Cancer

    RX-5902, a novel β-catenin modulator, potentiates the efficacy of immune checkpoint inhibitors in preclinical models of triple-negative breast Cancer oleh John J. Tentler, Julie Lang, Anna Capasso, Deog Joong Kim, Ely Benaim, Young B. Lee, Andrew Eisen, Stacey M. Bagby, Sarah J. Hartman, Betelehem W. Yacob, Brian Gittleman, Todd M. Pitts, Roberta Pelanda, S. Gail Eckhardt, Jennifer R. Diamond

    Diterbitkan 2020-11-01
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  9. 9
    Dual pharmacological targeting of the MAP kinase and PI3K/mTOR pathway in preclinical models of colorectal cancer.

    Dual pharmacological targeting of the MAP kinase and PI3K/mTOR pathway in preclinical models of colorectal cancer. oleh Todd M Pitts, Timothy P Newton, Erica L Bradshaw-Pierce, Rebecca Addison, John J Arcaroli, Peter J Klauck, Stacey M Bagby, Stephanie L Hyatt, Alicia Purkey, John J Tentler, Aik Choon Tan, Wells A Messersmith, S Gail Eckhardt, Stephen Leong

    Diterbitkan 2014-01-01
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  10. 10
    ATM kinase inhibitor AZD0156 in combination with irinotecan and 5-fluorouracil in preclinical models of colorectal cancer

    ATM kinase inhibitor AZD0156 in combination with irinotecan and 5-fluorouracil in preclinical models of colorectal cancer oleh S. Lindsey Davis, Sarah J. Hartman, Stacey M. Bagby, Marina Schlaepfer, Betelehem W. Yacob, Tonia Tse, Dennis M. Simmons, Jennifer R. Diamond, Christopher H. Lieu, Alexis D. Leal, Elaine B. Cadogan, Gareth D. Hughes, Stephen T. Durant, Wells A. Messersmith, Todd M. Pitts

    Diterbitkan 2022-10-01
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  11. 11
    Antitumor activity of the polo-like kinase inhibitor, TAK-960, against preclinical models of colorectal cancer

    Antitumor activity of the polo-like kinase inhibitor, TAK-960, against preclinical models of colorectal cancer oleh Peter J. Klauck, Stacey M. Bagby, Anna Capasso, Erica L. Bradshaw-Pierce, Heather M. Selby, Anna Spreafico, John J. Tentler, Aik Choon Tan, Jihye Kim, John J. Arcaroli, Alicia Purkey, Wells A. Messersmith, Keisuke Kuida, S. Gail Eckhardt, Todd M. Pitts

    Diterbitkan 2018-02-01
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  12. 12
    Tumor p-glycoprotein correlates with efficacy of PF-3758309 in in vitro and in vivo models of colorectal cancer.

    Tumor p-glycoprotein correlates with efficacy of PF-3758309 in in vitro and in vivo models of colorectal cancer. oleh Erica Lynn Bradshaw-Pierce, Erica Lynn Bradshaw-Pierce, Todd M Pitts, Aik-Choon eTan, Kelly eMcPhillips, Mark eWest, Daniel L Gustafson, Charles eHalsey, Leslie eNguyen, Nathan V Lee, Julie LC Kan, Brion William Murray, S. Gail eEckhardt

    Diterbitkan 2013-03-01
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  13. 13
    Examination of Wnt signaling as a therapeutic target for pancreatic ductal adenocarcinoma (PDAC) using a pancreatic tumor organoid library (PTOL).

    Examination of Wnt signaling as a therapeutic target for pancreatic ductal adenocarcinoma (PDAC) using a pancreatic tumor organoid library (PTOL). oleh Hayley J Hawkins, Betelehem W Yacob, Monica E Brown, Brandon R Goldstein, John J Arcaroli, Stacey M Bagby, Sarah J Hartman, Morgan Macbeth, Andrew Goodspeed, Thomas Danhorn, Robert W Lentz, Christopher H Lieu, Alexis D Leal, Wells A Messersmith, Peter J Dempsey, Todd M Pitts

    Diterbitkan 2024-01-01
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  14. 14
    A phase II clinical trial of the Aurora and angiogenic kinase inhibitor ENMD-2076 for previously treated, advanced, or metastatic triple-negative breast cancer

    A phase II clinical trial of the Aurora and angiogenic kinase inhibitor ENMD-2076 for previously treated, advanced, or metastatic triple-negative breast cancer oleh Jennifer R. Diamond, S. G. Eckhardt, Todd M. Pitts, Adrie van Bokhoven, Dara Aisner, Daniel L. Gustafson, Anna Capasso, Sharon Sams, Peter Kabos, Kathryn Zolman, Tiffany Colvin, Anthony D. Elias, Anna M. Storniolo, Bryan P. Schneider, Dexiang Gao, John J. Tentler, Virginia F. Borges, Kathy D. Miller

    Diterbitkan 2018-08-01
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  15. 15
    Cabozantinib sensitizes microsatellite stable colorectal cancer to immune checkpoint blockade by immune modulation in human immune system mouse models

    Cabozantinib sensitizes microsatellite stable colorectal cancer to immune checkpoint blockade by immune modulation in human immune system mouse models oleh Julie Lang, Alexis D. Leal, Juan A. Marín-Jiménez, Sarah J. Hartman, Jeremy Shulman, Natalie M. Navarro, Matthew S. Lewis, Anna Capasso, Stacey M. Bagby, Bethlehem W. Yacob, Morgan MacBeth, Brian M. Freed, S. Gail Eckhardt, Kimberly Jordan, Patrick J. Blatchford, Roberta Pelanda, Christopher H. Lieu, Wells A. Messersmith, Todd M. Pitts

    Diterbitkan 2022-11-01
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  16. 16
    Association of the Epithelial-to-Mesenchymal Transition (EMT) Phenotype with Responsiveness to the p21-Activated Kinase Inhibitor, PF-3758309, in Colon Cancer Models

    Association of the Epithelial-to-Mesenchymal Transition (EMT) Phenotype with Responsiveness to the p21-Activated Kinase Inhibitor, PF-3758309, in Colon Cancer Models oleh Todd M Pitts, Gillian N Kulikowski, Aik-Choon eTan, Brion William Murray, John J Arcaroli, John J Tentler, Anna eSpreafico, Heather M Selby, Maria I Kachaeva, Kelly L McPhillips, Blair C Britt, Erica Lynn Bradshaw-Pierce, Erica Lynn Bradshaw-Pierce, Wells A Messersmith, Marileila eVarella-Garcia, S. Gail eEckhardt

    Diterbitkan 2013-03-01
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  17. 17
    Testing Cancer Immunotherapy in a Human Immune System Mouse Model: Correlating Treatment Responses to Human Chimerism, Therapeutic Variables and Immune Cell Phenotypes

    Testing Cancer Immunotherapy in a Human Immune System Mouse Model: Correlating Treatment Responses to Human Chimerism, Therapeutic Variables and Immune Cell Phenotypes oleh Juan A. Marín-Jiménez, Anna Capasso, Matthew S. Lewis, Stacey M. Bagby, Sarah J. Hartman, Jeremy Shulman, Natalie M. Navarro, Hui Yu, Hui Yu, Chris J. Rivard, Chris J. Rivard, Xiaoguang Wang, Jessica C. Barkow, Degui Geng, Adwitiya Kar, Ashley Yingst, Dejene M. Tufa, James T. Dolan, Patrick J. Blatchford, Brian M. Freed, Brian M. Freed, Raul M. Torres, Raul M. Torres, Eduardo Davila, Eduardo Davila, Jill E. Slansky, Jill E. Slansky, Roberta Pelanda, Roberta Pelanda, S. Gail Eckhardt, Wells A. Messersmith, Wells A. Messersmith, Jennifer R. Diamond, Jennifer R. Diamond, Christopher H. Lieu, Michael R. Verneris, Jing H. Wang, Jing H. Wang, Katja Kiseljak-Vassiliades, Katja Kiseljak-Vassiliades, Todd M. Pitts, Todd M. Pitts, Julie Lang

    Diterbitkan 2021-03-01
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