Hasil Pencarian - Thomas R. Caulfield

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  1. 1
    Small molecule inhibitors of mesotrypsin from a structure-based docking screen.

    Small molecule inhibitors of mesotrypsin from a structure-based docking screen. oleh Olumide Kayode, Zunnan Huang, Alexei S Soares, Thomas R Caulfield, Zigang Dong, Ann M Bode, Evette S Radisky

    Diterbitkan 2017-01-01
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  2. 2
    FAM111A protects replication forks from protein obstacles via its trypsin-like domain

    FAM111A protects replication forks from protein obstacles via its trypsin-like domain oleh Yusuke Kojima, Yuka Machida, Sowmiya Palani, Thomas R. Caulfield, Evette S. Radisky, Scott H. Kaufmann, Yuichi J. Machida

    Diterbitkan 2020-03-01
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  3. 3
    Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14

    Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14 oleh Hezi Hayun, Matt Coban, Ashok Kumar Bhagat, Eden Ozer, Lital Alfonta, Thomas R. Caulfield, Evette S. Radisky, Niv Papo

    Diterbitkan 2023-03-01
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  4. 4
    In Silico Investigation of Parkin-Activating Mutations Using Simulations and Network Modeling

    In Silico Investigation of Parkin-Activating Mutations Using Simulations and Network Modeling oleh Naeyma N. Islam, Caleb A. Weber, Matt Coban, Liam T. Cocker, Fabienne C. Fiesel, Wolfdieter Springer, Thomas R. Caulfield

    Diterbitkan 2024-03-01
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  5. 5
    Structural Models for the Dynamic Effects of Loss-of-Function Variants in the Human SIM1 Protein Transcriptional Activation Domain

    Structural Models for the Dynamic Effects of Loss-of-Function Variants in the Human SIM1 Protein Transcriptional Activation Domain oleh Mathew A. Coban, Patrick R. Blackburn, Murray L. Whitelaw, Mieke M. van Haelst, Paldeep S. Atwal, Thomas R. Caulfield

    Diterbitkan 2020-09-01
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  6. 6
    Whole Exome Sequencing and Molecular Modeling of a Missense Variant in TNFAIP3 That Segregates with Disease in a Family with Chronic Urticaria and Angioedema

    Whole Exome Sequencing and Molecular Modeling of a Missense Variant in TNFAIP3 That Segregates with Disease in a Family with Chronic Urticaria and Angioedema oleh Antoneicka L. Harris, Patrick R. Blackburn, John E. Richter, Jennifer M. Gass, Thomas R. Caulfield, Ahmed N. Mohammad, Paldeep S. Atwal

    Diterbitkan 2018-01-01
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  7. 7
    Phosphorylation by PINK1 releases the UBL domain and initializes the conformational opening of the E3 ubiquitin ligase Parkin.

    Phosphorylation by PINK1 releases the UBL domain and initializes the conformational opening of the E3 ubiquitin ligase Parkin. oleh Thomas R Caulfield, Fabienne C Fiesel, Elisabeth L Moussaud-Lamodière, Daniel F A R Dourado, Samuel C Flores, Wolfdieter Springer

    Diterbitkan 2014-11-01
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  8. 8
    Genomic Observations of a Rare/Pathogenic <i>SMAD3</i> Variant in Loeys–Dietz Syndrome 3 Confirmed by Protein Informatics and Structural Investigations

    Genomic Observations of a Rare/Pathogenic <i>SMAD3</i> Variant in Loeys–Dietz Syndrome 3 Confirmed by Protein Informatics and Structural Investigations oleh John E. Richter, Ayesha Samreen, Charitha Vadlamudi, Haytham Helmi, Ahmed N. Mohammad, Klaas Wierenga, Stephanie Hines, Paldeep S. Atwal, Thomas R. Caulfield

    Diterbitkan 2019-05-01
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  9. 9
    Examination of Molecular Effects of MYLK Deletion in a Patient with Extensive Aortic, Carotid, and Abdominal Dissections That Underlie the Genetic Dysfunction

    Examination of Molecular Effects of MYLK Deletion in a Patient with Extensive Aortic, Carotid, and Abdominal Dissections That Underlie the Genetic Dysfunction oleh Sarah K. Macklin, Katelyn A. Bruno, Charitha Vadlamudi, Haytham Helmi, Ayesha Samreen, Ahmed N. Mohammad, Stephanie Hines, Paldeep S. Atwal, Thomas R. Caulfield

    Diterbitkan 2020-01-01
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  10. 10
    Mycolactone: A Broad Spectrum Multitarget Antiviral Active in the Picomolar Range for COVID-19 Prevention and Cure

    Mycolactone: A Broad Spectrum Multitarget Antiviral Active in the Picomolar Range for COVID-19 Prevention and Cure oleh Seth Osei Asiedu, Yash Gupta, Vlad Nicolaescu, Haley Gula, Thomas R. Caulfield, Ravi Durvasula, Prakasha Kempaiah, Samuel K. Kwofie, Michael D. Wilson

    Diterbitkan 2023-04-01
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  11. 11
    A novel histone deacetylase inhibitor W2A-16 improves the barrier integrity in brain vascular endothelial cells

    A novel histone deacetylase inhibitor W2A-16 improves the barrier integrity in brain vascular endothelial cells oleh Yasuteru Inoue, Yingxue Ren, Shuwen Zhang, Michael Bamkole, Naeyma N. Islam, Manikandan Selvaraj, Wenyan Lu, Wenyan Lu, Thomas R. Caulfield, Yonghe Li, Takahisa Kanekiyo, Takahisa Kanekiyo

    Diterbitkan 2024-07-01
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  12. 12
    A Virtual Screening Platform Identifies Chloroethylagelastatin A as a Potential Ribosomal Inhibitor

    A Virtual Screening Platform Identifies Chloroethylagelastatin A as a Potential Ribosomal Inhibitor oleh Thomas R. Caulfield, Karen E. Hayes, Yushi Qiu, Mathew Coban, Joon Seok Oh, Amy L. Lane, Takehiko Yoshimitsu, Lori Hazlehurst, John A. Copland, Han W. Tun

    Diterbitkan 2020-10-01
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  13. 13
    Decoding Immuno-Competence: A Novel Analysis of Complete Blood Cell Count Data in COVID-19 Outcomes

    Decoding Immuno-Competence: A Novel Analysis of Complete Blood Cell Count Data in COVID-19 Outcomes oleh Prakasha Kempaiah, Claudia R. Libertin, Rohit A. Chitale, Islam Naeyma, Vasili Pleqi, Johnathan M. Sheele, Michelle J. Iandiorio, Almira L. Hoogesteijn, Thomas R. Caulfield, Ariel L. Rivas

    Diterbitkan 2024-04-01
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  14. 14
    Unveiling an indole alkaloid diketopiperazine biosynthetic pathway that features a unique stereoisomerase and multifunctional methyltransferase

    Unveiling an indole alkaloid diketopiperazine biosynthetic pathway that features a unique stereoisomerase and multifunctional methyltransferase oleh Garrett Deletti, Sajan D. Green, Caleb Weber, Kristen N. Patterson, Swapnil S. Joshi, Tushar M. Khopade, Mathew Coban, James Veek-Wilson, Thomas R. Caulfield, Rajesh Viswanathan, Amy L. Lane

    Diterbitkan 2023-05-01
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  15. 15
    Characterization of a Pathogenic Variant in the ABCD1 Gene Through Protein Molecular Modeling

    Characterization of a Pathogenic Variant in the ABCD1 Gene Through Protein Molecular Modeling oleh John E. Richter Jr., Charitha Vadlamudi, Sarah K. Macklin, Ayesha Samreen, Haytham Helmi, Daniel Broderick, Ahmed N. Mohammad, Stephanie L. Hines, Jay A. VanGerpen, Paldeep S. Atwal, Thomas R. Caulfield

    Diterbitkan 2020-01-01
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  16. 16
    Attacking COVID-19 Progression Using Multi-Drug Therapy for Synergetic Target Engagement

    Attacking COVID-19 Progression Using Multi-Drug Therapy for Synergetic Target Engagement oleh Mathew A. Coban, Juliet Morrison, Sushila Maharjan, David Hyram Hernandez Medina, Wanlu Li, Yu Shrike Zhang, William D. Freeman, Evette S. Radisky, Karine G. Le Roch, Carla M. Weisend, Hideki Ebihara, Thomas R. Caulfield

    Diterbitkan 2021-05-01
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  17. 17
    The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity

    The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity oleh Maya Ando, Fabienne C. Fiesel, Roman Hudec, Thomas R. Caulfield, Kotaro Ogaki, Paulina Górka-Skoczylas, Dariusz Koziorowski, Andrzej Friedman, Li Chen, Valina L. Dawson, Ted M. Dawson, Guojun Bu, Owen A. Ross, Zbigniew K. Wszolek, Wolfdieter Springer

    Diterbitkan 2017-04-01
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  18. 18
    Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity

    Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity oleh Elke Bogaert, Steven Boeynaems, Masato Kato, Lin Guo, Thomas R. Caulfield, Jolien Steyaert, Wendy Scheveneels, Nathalie Wilmans, Wanda Haeck, Nicole Hersmus, Joost Schymkowitz, Frederic Rousseau, James Shorter, Patrick Callaerts, Wim Robberecht, Philip Van Damme, Ludo Van Den Bosch

    Diterbitkan 2018-07-01
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  19. 19
    An activating germline IDH1 variant associated with a tumor entity characterized by unilateral and bilateral chondrosarcoma of the mastoid

    An activating germline IDH1 variant associated with a tumor entity characterized by unilateral and bilateral chondrosarcoma of the mastoid oleh Patrick R. Blackburn, Jodi M. Carter, Devin Oglesbee, Jennifer J. Westendorf, Brian A. Neff, Damian Stichel, David W. Tsen, Ralitza H. Gavrilova, Pieter Wesseling, Andreas von Deimling, Thomas R. Caulfield, Eric W. Klee, Stefan Pusch, Carrie Y. Inwards

    Diterbitkan 2020-10-01
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  20. 20
    Structural and Functional Characterization of the Most Frequent Pathogenic PRKN Substitution p.R275W

    Structural and Functional Characterization of the Most Frequent Pathogenic PRKN Substitution p.R275W oleh Bernardo A. Bustillos, Liam T. Cocker, Mathew A. Coban, Caleb A. Weber, Jenny M. Bredenberg, Paige K. Boneski, Joanna Siuda, Jaroslaw Slawek, Andreas Puschmann, Derek P. Narendra, Neill R. Graff-Radford, Zbigniew K. Wszolek, Dennis W. Dickson, Owen A. Ross, Thomas R. Caulfield, Wolfdieter Springer, Fabienne C. Fiesel

    Diterbitkan 2024-09-01
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